Freiburg University 2006
The team (all stars)
The project: DNA Folding
No.1 - The Pipe
The idea is to design a strand of DNA such that it wraps into a specific shape.
There are three different stages for this project: First, the DNA should fold into a two-dimensional rectangular sheet. Secondly, this sheet should wrap itself up into the shape of a short pipe. And last, these little pipes should hook themselves up to each other such that they form one single long pipe (more details).
No.2 - Haute Couture: Barbie Nanoatelier
Once the process of DNA folding into 3D structures is understood, shapes can be chosen arbitrarily. The idea of the Barbie Nanoatelier is that the DNA should wrap into a 3D T-Shirt, 3D Pants, etc.
"sea of parts"
We need a library of molecular primitives that could be interchanged in the desirable way for a bottom-up design on the nanometer scale. Registry of DNA molecular parts and standardization is an actual question of bionanotechnology. We just put first examples of a new class of BioBricks - ORIGAMI BioBriks into depository and publish basic ideas , , . We try to merge a ‘dead DNA’ with an ‘alive DNA’.
We also try to pump some aesthetic principles and rules (symmetry, periodic patterns, recursion, and plasticity) into our creatures. We like it because it needs a huge of imagination and really very difficult. Nobody can build a bra! - von Neumann's self-reproducing ... bra :))
Sketches - T-Shirt from DNA
Hey, venture capitalists, where are you? The price of all of 50 billion T-Shirts would be only 7200bases x €0.17/base = €1224. Don’t miss the chance. It could be a great business tomorrow!
Jobs: Still looking for catwalk models!!
No.3 - Individual projects
Other projects and prices could be found on individual Mutant's pages (Real iPod nano, Captain Nemo). In addition, you can find some hot information on ‘GEM Freiburg Fellow 2006’ page. The other toys will be unconventional computing, cryptography, nanoelectronics, nanooptics, drug delivery systems, smart nanomaterials, nanoswarm, eventually an artificial life and Origami Man. Time is money!
Now we see it could be cheaper, but it will need a great intellectual impact. So, we’re opened for sponsors and relationships.
As I understand it, the idea is to create a "life automaton" consisting of 6 proteins? That is what I took out of your proposal. That seems quite ambitioned, but I can't really judge it, and even if it is quite ambitioned, that does not mean that it is bad, of course.
My understanding says that you are using 6000 € for denovo synthesis of 6 genes required for making minimal life. Right?
So, what if after all the simulations and tests on the computer, you order the DNA for minimal life and it turns out that it doesn't work... What will you do then?
This is because biology is unpredictable and you must not assume that the DNA which you order will work in the first time itself... You must keep some backup money or plans...
You have to separate specifically the general and specific objectives to long and short time; implications, obstacles and limitations.
OK, fine.. So you want to go in a completely different direction by creating alternative life.. Good.. All the best for this project.
Well, if you want to go to the extremes then are you limiting yourself to already established phenomena such as DNA, membranes, etc. You may want to adopt a completely new and novel ideas which might be simpler than DNA and other stuff of the normal cell.
So, keep all the options open. Research the literature well and create Artificial Life...
No more child labour, just molecule labour :)
Hey Mutant, have a look!
The easy and serious way. Ja oder Nein?
DNA nanotechnology for newborn Mutants
These people do great things
Albert Libchaber 
Carlos Bustamante's lab 
Darko Stefanovic 
David Deamer 
David Liu 
Ehud Shapiro 
Eric Kool’s group 
Erik Winfree 
Fred Menger’s group 
Friedrich Simmel 
Gerald Joyce 
Hao Yan 
Jack Szostak’s lab 
Len Adleman 
Luc Jaeger 
Molecular Computing Group 
Ned Seeman 
Peixuan Guo 
Pier Luigi Luisi’s group 
'Protolife' by Norman Packard & Mark Bedau 
Radhika Nagpal 
Richard Kiehl 
Seung-Wuk Lee 
Steen Rasmussen 
Steven Benner 
Thomas LaBean 
William Shih 
Sorry whom aren’t on the list!
An Analysis of Synthetic Biology Research in Europe and North America  SB database  DNA synthesis: ATG-Biosynthetics  febit  'Spiegel' about iGEM competition on August 14, 2006  'Neue Zürcher Zeitung' about SB on August 23, 2006  New GEM on the simiki wiki page