Answer1

From 2006.igem.org

1. Heat Unstable Nucleoid Protein
2. HU stimulates trascription using lambda phage template
3. It is made of 2 subunits: HU alpha and HU beta
4. It is an abundant non-specific DNA binding protein which is highly conserved between prokaryotes
5. About 30,000 to 55,000 HU molecules per cell exist in the exponentially growing cells of E. coli W3110. Indicating that HU, together with Fis, forms a major nucleoid component in the growing E. coli cell
6. Considered prokaryotic homolog of eukaryotic histones which restrains DNA supercoils in the nucleoid
7. Certain fraction of HU is associated with ribosomes
8. At saturation, HU dimers may be associated, on average, every 300 to 400 bp of the E. coli genome
9. Upon entry into the stationary phase, the HU level started to decrease gradually, decreasing to less than one-third of the maximum level in the late stationary phase