Berk2006dummypage

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'''Undergrads'''
'''Undergrads'''
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[[Bryan Hernandez]]<br>
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Bryan Hernandez<br>
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[[Matt Fleming]]<br>
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Matt Fleming<br>
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[[Kaitlin A. Davis]]<br>
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Kaitlin A. Davis<br>
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[[Jennifer Lu]]<br>
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Jennifer Lu<br>
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[[Samantha Liang]]<br>
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Samantha Liang<br>
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[[Daniel Kluesing]]<br>
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Daniel Kluesing<br>
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[[Will Bosworth]]<br>
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Will Bosworth<br>
'''Postdocs'''
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[[John E. Dueber]]<br>
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John E. Dueber<br>
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[[J. Christopher Anderson]]<br>
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J. Christopher Anderson<br>
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'''Faculty Advisors'''
'''Faculty Advisors'''
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[[Adam P. Arkin]]<br>
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Adam P. Arkin<br>
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[[Jay D. Keasling]]<br>
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Jay D. Keasling<br>
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Revision as of 02:39, 28 October 2006

berk2006dummypage

Addressable Conjugation in Bacterial Networks

Networks of interacting cells provide the basis for neural learning. We have developed the process of addressable conjugation for communication within a network of E. coli bacteria. Here, bacteria send messages to one another via conjugation of plasmid DNAs, but the message is only meaningful to cells with a matching address sequence. In this way, the Watson Crick base-pairing of addressing sequences replaces the spatial connectivity present in neural systems. To construct this system, we have adapted natural conjugation systems as the communication device. Information contained in the transferred plasmids is only accessable by "unlocking" the message using RNA based 'keys'. The resulting addressable conjugation process is being adapted to construct a network of NAND logic gates in bacterial cultures. Ultimately, this will allow us to develop networks of bacteria capable of trained learning.

The specific Aims of our project were:

  1. Construct efficient riboregulator lock/key pairs
  2. Control ***conjugation**
  3. Show ***them together***
  4. Develop a set of promoter tools to tune gene regulation


Team


Undergrads

Bryan Hernandez
Matt Fleming
Kaitlin A. Davis
Jennifer Lu
Samantha Liang
Daniel Kluesing
Will Bosworth

Postdocs

John E. Dueber
J. Christopher Anderson

Faculty Advisors

Adam P. Arkin
Jay D. Keasling

The Details


Riboregulators
Conjugation
NAND
Networks
Promoter Engineering




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