Berkeley2006-NetworksMain

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The ability to maintain, send, and receive plasmids is lock-controlled

Berkeley2006 Conjugation7.GIF

Nodes are Built from Multiple Cell Types

Berkeley2006 Net2.GIF

Concentration in Culture Gives Graded Responses

Berkeley2006 Net3.GIF

Trainable Networks are Built from Nodes

Berkeley2006 Net1.GIF


Each cell has a complete lock-dependent communication system

Each cell has a unique lock address and a key message to send

Communication between a sender and a receiver is therefore restricted to cells that are a donor with the key that unlocks the recipient's lock address

There are many lock and key pairs, but the partnering between potential communicating cells is restricted in layers--layer 1 cells only contain keys that correspond to layer 2 locks. Layer 2 keys only unlock layer 3 locks, etc.

Within a layer, each n+1 layer lock component has a key with all permutations of layer n. If each layer has 10 addresses (locks) , there are 10x10, or 100 unique genotypes within each member of a layer is able to communicate with each member of the previous layer.

At the top of the layers is a set of training cells which direct a positive selectable marker to cells that contain their key sequence. The 'input' to the training system is therefore a set of key sequences.

At the end of the layers is a set of training cells that direct a negatively selectable marker, or "kill" signal contained in their key sequence. All cells able to receive the kill signal die.


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