Brown:Projects

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== Bacterial Freeze Tag ==
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==[[Overview]]==
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<h3>Brown 2006 iGEM entry </h3>
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==[[Sender Cell]]==
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As the race to the finish draws near for iGEM 2006, our team has compiled a detailed summary of our summers work.  This includes our initial ideas, designs, models and the parts that we have added to the registry.  We began the summer with grand plans to design a game of bacterial freeze tag, modeled after the popular children's game where one player tries to catch the other.  Our efforts were then switched to the extension of the bi-stable toggle switch and the design of a tri-stable toggle switch.  Our projects highlight the team's creative and innovative approaches to designing and engineering working biological systems.
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==[[AHL Sensor]]==
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Click here to see our BioBricks! [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2006partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2006&group=Brown Brown iGEM 2006 Parts]
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==[['Freeze Machine']]==
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A promoter that is regulated by LacI will promote the production of LasI, MotB, and cI. This will subsequently inhibit the production of CFP and LasR. In the presence of LacI, however, MotB, LasI, and cI will not be produced. CFP will therefore be produced along with LasR and LacI. This results in the "freezing" of the cell.
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==[[Unfreeze Mechanism]]==
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<h3>[[Brown:Bacterial Freeze Tag | Bacterial Freeze Tag]] </h3>
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== Magnetotactic Bacteria ==
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*[[Brown:Bacterial_Freeze_Tag#Overview |Overview]]
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*[[Brown:Bacterial_Freeze_Tag#Sender cell | Sender cell ]]
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*[[Brown:Bacterial_Freeze_Tag#Receiver cell | Receiver cell ]]
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*[[Brown:Bacterial_Freeze_Tag#Challenges| Challenges ]]
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'''Avadin-Biotin Complex'''
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To create magnetosomes covered in Avadin.  The basic idea is to create a fusion protein from MagA and Avadin, then isolate the magnetic particles, which will now be coated in avadin.  Avadin forms one of the strongest bindings known with the molecule biotin.
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<h3>[[Brown:Tri-Stable toggle switch|Tri-Stable toggle switch]]</h3>
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*[[Brown:Tri-Stable_toggle_switch|Introduction to the project]]
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*[[Brown:Tri-Stable toggle switch#Modeling the tri-stable toggle switch | Modeling the tri-stable switch]]
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*[[Brown:Tri-Stable toggle switch#What we achieved| What we achieved]]
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*[[Brown:Tri-Stable toggle switch#Challenges | Challenges ]]
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*[[Brown:Tri-Stable toggle switch#Challenges | Future work ]]
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Bayer, E. A. and Wilchek, M. (1978). The avidin-biotin complex as a tool in molecular biology. Trends Biochem. Sci. 3, N237-N239.
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<h3>[[Brown:Team logistics | Team Logistics ]] </h3>
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http://www.weizmann.ac.il/Biological_Chemistry/scientist/Bayer/BayerAvidin.html  great review
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*[[Brown:Team logistics|How we got here]]
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*[[Brown:Team_logistics|Challenges]]
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*[[Brown:Team_logistics|Future work]]
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http://www.avidity.com/apps.html  current applications of tagging biotin
 
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http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=92791044
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Artifical synthesized Gene coding for avidin
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__NOTOC__

Latest revision as of 03:04, 2 November 2006

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Brown 2006 iGEM entry

As the race to the finish draws near for iGEM 2006, our team has compiled a detailed summary of our summers work. This includes our initial ideas, designs, models and the parts that we have added to the registry. We began the summer with grand plans to design a game of bacterial freeze tag, modeled after the popular children's game where one player tries to catch the other. Our efforts were then switched to the extension of the bi-stable toggle switch and the design of a tri-stable toggle switch. Our projects highlight the team's creative and innovative approaches to designing and engineering working biological systems.

Click here to see our BioBricks! Brown iGEM 2006 Parts

Bacterial Freeze Tag

Tri-Stable toggle switch

Team Logistics



Personal tools
Past/present/future years