Freiburg University 2006

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== The Team ==
== The Team ==
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Students:
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====Students====
*[[User:Daniel_Hautzinger|Daniel Hautzinger]]
*[[User:Daniel_Hautzinger|Daniel Hautzinger]]
*[[User:Marc_Wilnauer|Marc Wilnauer]]
*[[User:Marc_Wilnauer|Marc Wilnauer]]
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*[[User:Mona_Klein|Mona Klein]]
*[[User:Mona_Klein|Mona Klein]]
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iGEM instructor:
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====iGEM instructor====
*[[User:Andrei_Kouznetsov|Andrei Kouznetsov]]
*[[User:Andrei_Kouznetsov|Andrei Kouznetsov]]
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Faculty/staff:
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====Faculty/staff====
*[[User:Svetlana_Santer|Svetlana Santer]]
*[[User:Svetlana_Santer|Svetlana Santer]]
== The project: DNA Folding==
== The project: DNA Folding==
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===Basic Idea:===
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===Basic Idea===
====Abstract====
====Abstract====
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* [http://omnibus.uni-freiburg.de/~kouznet/GS-design.pdf Genetic systems design from the DNA modules]
* [http://omnibus.uni-freiburg.de/~kouznet/GS-design.pdf Genetic systems design from the DNA modules]
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== Old project idea==
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== Old project ideas==
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* [http://omnibus.uni-freiburg.de/~kouznet/life6000.pdf Life with a price of 6000 €]
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Now we see it could be cheaper, but it will need a great intellectual impact. So, we’re opened for '''sponsors and relationships'''.
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=== Comments ===
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As I understand it, the idea is to create a "life
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automaton" consisting of 6 proteins? That is what I took
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out of your proposal. That seems quite ambitioned, but I
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can't really judge it, and even if it is quite
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ambitioned, that does not mean that it is bad, of
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course.
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My understanding says that you are using 6000 € for
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denovo synthesis of 6 genes required for making minimal
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life. Right?
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So, what if after all the simulations and tests on the
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computer, you order the DNA for minimal life and it
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turns out that it doesn't work... What will you do then?
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This is because biology is unpredictable and you must
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not assume that the DNA which you order will work in the
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first time itself... You must keep some backup money or
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plans...
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You have to separate specifically the general and specific
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objectives to long and short time; implications, obstacles
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and limitations.
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OK, fine.. So you want to go in a completely different
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direction by creating alternative life.. Good.. All the
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best for this project.
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Well, if you want to go to the extremes then are you
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limiting yourself to already established phenomena such
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as DNA, membranes, etc. You may want to adopt a
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completely new and novel ideas which might be simpler
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than DNA and other stuff of the normal cell.
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So, keep all the options open. Research the literature
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well and create Artificial Life...
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=== Questions ===
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* - Dilettante: "Where is a place of synthetic biology here - good old gene engineering > bio-nanotechnology > orthogonal life > artificial life > artificial intelligence?" <br> - Expert: "Hmmm..."
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* - Professor: "What is new in Synthetic Biology?" <br> - Student: "Wiki!!!"
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* People on a street: <br> - "What is a synthetic biology - science or technology?" <br> - "Expedition."
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* - Shrödinger: “What is life?” <br> - Alice: “It’s a play where rules are constantly changed.”
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* [[Life_6000 Life with a price of 6000 €]]
== Hey Mutant, have a look! ==
== Hey Mutant, have a look! ==

Revision as of 21:07, 28 August 2006

Welcome! We are Alife Mutants.

Uf101.jpg

This term was invented by Martin Schneider on the Rule 110 Winter Workshop in 2004 [1]. We play without rules. We discover the rules that govern life, the universe and everything to exploit these rules and to create Artificial Life. Our short-time aim is the trip to Boston in November 2006 to take a prize in the iGEM.

Freiburg Team 06.JPG

The Freiburg Team (well, at least half of it...) from left to right: Irina Petrova, Andrei Kouznetsov, Daniel Hautzinger.


Contents

The Team

Students

iGEM instructor

Faculty/staff

The project: DNA Folding

Basic Idea

Abstract

The idea is to design a strand of DNA such that it wraps into some meaningful shape. There are three different stages for this project: First, the DNA should fold into a two-dimensional rectangular sheet. Secondly, this sheet should wrap itself up into the shape of a short pipe. And last, these little pipes should hook themselves up to each other such that they form one single long pipe.

Scetches - Pipes

Pipes - Stage 1
Pipes - Stage 2
Pipes - Stage 3


The DNA sequence for the Pipes design can be found here.

Application: Barbie Nanoatelier

Once the process of DNA folding into 3D-structures is understood, shapes can be chosen arbitrarily. The idea of the Barbie Nanoatelier is that the DNA should wrap into a 3D-TShirt, 3D-Pants, etc.

Scetches - TShirt

TShirt - Stage 1
TShirt - Stage 2
TShirt - Stage 3
TShirt - Stage 4


Scetches - Bluse

Bluse - Stage 1
Bluse - Stage 2


The DNA sequence for the Bluse design can be found here.

GEM Freiburg

Club

SB Preliminary

Old project ideas

Hey Mutant, have a look!

The easy and serious way

These people do great things

Albert Libchaber [2] Carlos Bustamante's lab [3] David Deamer [4] Eric Kool’s group [5] Erik Winfree [6] Fred Menger’s group [7] Jack Szostak’s lab [8] Norman Packard’s Protolife [9] Pier Luigi Luisi’s group [10] Radhika Nagpal [11] Steven Benner’s group [12]

Local

An Analysis of Synthetic Biology Research in Europe and North America [13] DNA synthesis: ATG-Biosynthetics [14]

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