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| - | '''<big>iGEM 2005</big> - The summer 2005 intercollegiate Genetically Engineered Machine competition.'''
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| - | ==Participating Schools==
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| - | {| width=400 align=center +
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| - | |[[Berkeley]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Berkeley Parts] +
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| - | - |[[Caltech]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?group=iGEM&group=iGEM_Caltech Parts] [http://www.cds.caltech.edu/~murray/synbio/wiki/index.php WIKI]
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| - | |[[Cambridge]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Cambridge Parts] [http://www.ccbi.cam.ac.uk/iGEM2005/index.php/Main_Page WIKI]
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| - | |[[Davidson]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Davidson Parts]
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| - | - |[[ETH Zurich]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_ETHZ Parts] +
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| - | - |[[Harvard]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Harvard Parts] [http://karma.med.harvard.edu/wiki/iGEM_2005 WIKI] +
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| - | - |[http://model.mit.edu/igem/index.php?title=People MIT] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_MIT Parts] [http://model.mit.edu/igem WIKI] +
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| - | - |[[Oklahoma]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Oklamhoma Parts] +
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| - | - |[[Penn State]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Penn_State Parts] +
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| - | - |[[Princeton]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Princeton Parts] [http://ehukai.ee.princeton.edu/wi/index.php WIKI] +
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| - | - |[[Toronto]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Toronto Parts] +
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| - | - |[[UCSF]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UCSF Parts] +
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| - | - |[[UT Austin]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UTAustin Parts] +
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| - | - |[http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Registry Registry Parts] +
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| - | - |} +
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| - | - +
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| - | - ==Events== +
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| - | - *[http://parts2.mit.edu/r/parts/htdocs/iGEM2005/ttt.cgi Teacher's Workshop] - May 15-15, 2005 +
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| - | - **[[Parts, Devices, Systems & Engineering Theory]] +
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| - | - **[[Risks and Rewards]] +
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| - | - **[[Notes on Tom Knight's talk]] +
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| - | - **[http://web.mit.edu/endy/www/scraps/talks/iGEM/Silver.yeast.ppt Pam Silver's yeast powerpoint] +
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| - | - *Jamboree, November 5-6, 2005 (to change the name of the Jamboree, please send Drew Endy a check for $30,000,000) +
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| - | - +
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| - | - ==Papers for Students to Read== +
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| - | - ===General Review Papers=== +
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| - | - *A. Malcolm Campbell. 2005. Meeting Report: Synthetic Biology Jamboree for Undergraduates. Cell Biology Education. 4: 19 - 23. (Meeting Report for 2004 Jamboree) [http://www.cellbioed.org/pdf/04-11-0047.pdf URL] +
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| - | - *Dan Ferber. 2004. Microbes Made to Order. Science. Vol. 303: 158 - 161. (Good general overview), [http://www.sciencemag.org/cgi/content/full/303/5655/158 URL] +
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| - | - *Jeff Hasty, David McMillen, and J. J. Collins. 2002. Engineered Gene Circuits. Nature. Vol. 420: 224 - 230. (Scholarly Review Paper), [http://www.nature.com/nature/journal/v420/n6912/abs/nature01257_fs.html URL] +
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| - | - +
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| - | - *Philip Ball. 2004. Starting from Scratch. Nature. Vol. 431: 624 - 626. (OK general overview), [http://www.nature.com/news/2004/041004/pf/431624a_pf.html URL] +
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| - | - +
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| - | - *Editors of Nature. 2004. Futures of Artificial Life. Nature. Vol. 431: 613. (Editorial that addresses ethical considerations), [http://www.bio.davidson.edu/courses/synthetic/papers/Synthetic_Editorial.pdf URL] +
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| - | - +
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| - | - ===Research Papers in Synthetic Biology=== +
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| - | - *Timothy S. Gardner, Charles R. Cantor, and James J. Collins. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature. Vol. 403. 339 - 342. (Bistable gene regulatory network, toggled by transient chemical or thermal induction, to serve as cellular memory) +
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| - | - +
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| - | - *Robert T. Batey, Sunny D. Gilbert, and Rebecca K. Montange. 2004. Structure of a Natural Guanine-responsive Riboswitch Complexed with a Metabolite Hypoxanthine. Nature. Vol. 432. 411 - 415. (Distinguishes Riboswitches from Aptamers and Antiswitches; also shows 3D structure of aptamer and ligand) +
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| - | - +
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| - | - *News Summary of Batey et al. 2004. (Batey et al., paper above) +
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| - | - +
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| - | - *Laising Yen et al. 2004. Exogenous Controlof Mammalian Gene Expression through Modulation of RNA Self-cleavage. Nature. Vol. 431: 471 - 476. (mRNA-mediated regulation of translation) +
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| - | - +
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| - | - *Yina Kuang, Israel Biran, and David R. Walt. 2004. Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays. Analytical Chemistry. Vol. 76: 6282 - 6286. (Analysis of two promoters) +
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| - | - +
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| - | - *Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Conner, and James C. Liao. 2004. Design of artificial cell-cell communication using gene and metabolic networks. PNAS. 101(8): 2299-2304. (Quorum sensor using acetate signal) +
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| - | - *Hideki Kobayashi, Mads Kaern, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins. Programmable cells: Interfacing natural and engineered gene networks. PNAS. 101(22): 8414-8419. (Toggle switch interfaced with 1) SOS signaling pathway for DNA damage response and 2) quorum sensing signalling pathway) +
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| - | - *Sara Hooshangi, Stephan Thiberge, and Ron Weiss. 2005. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. PNAS. 102(10): 3581–3586. (Basic Research Paper) +
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| - | - +
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| - | - *Bayer, Travis S. and Christina D . Smolke. 2005. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23 (3): 337 - 343. (Antiswithces that turn off or on mRNA translation, regulated by amptamer binding ligands) +
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| - | - +
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| - | - *Isaacs, Farren J. and James J. Collins. 2005. Plug-and-play with RNA. Nature Biotechnology. 23 (3): 306 -307. (Commentary on Bayer & Smolke, 2005.) +
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| - | - +
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| - | - * Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss. 2005. A synthetic multicellular system for programmed pattern formation. Nature. Vol. 434:1130-1134 (Cool patterns, seeded with senders, with receivers responding to chemical gradients) [http://www.nature.com/nature/journal/v434/n7037/abs/nature03461.html URL] +
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| - | - +
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| - | - ===Mathematical Modeling in Synthetic Biology=== +
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| - | - * Hasty J, McMillen D, Isaacs F, Collins JJ. 2001. Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet. 2001 Apr;2(4):268-79. +
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| - | - * Guet, Călin C., Elowitz, Michael B., Hsing, Weihong, Leibler, Stanislas Combinatorial Synthesis of Genetic Networks Science 2002 296: 1466-1470 +
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| - | - +
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| - | - * McAdams HH, Arkin A. Simulation of prokaryotic genetic circuits. Annu Rev Biophys Biomol Struct. 1998; 27:199-224. [http://dx.doi.org/10.1146/annurev.biophys.27.1.199 Link] +
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| - | - +
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| - | - ==Possible Fun Groups== +
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| - | - #[[Awards Panel]] +
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| - | - #[[Jamboree Planning]] +
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| - | - #[[Editorial Board]] +
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| - | - #[[Standards of Practice]] +
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| - | - #[[iGEM 2006 Planning]] +
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| - | - #[[Others (Publicity?)]] +
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| - | - +
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| - | - ==Resources== +
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| - | - #[[Blue Heron Point of Contact]] +
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| - | - #[[Part Nicknames]] +
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| - | - #[[Lab Protocols]] +
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| - | - +
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| - | - Please see [http://meta.wikipedia.org/wiki/MediaWiki_i18n documentation on customizing the interface] +
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| - | - and the [http://meta.wikipedia.org/wiki/MediaWiki_User%27s_Guide User's Guide] for usage and configuration help. +
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| - | - ==Funding== +
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| - | - +
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| - | - iGEM is an initiative of the MIT [http://icampus.mit.edu/ iCampus] program, which is funded by Microsoft Corp. iCampus sponsors faculty innovations in educational technology, helps incubate them through classroom use, and promotes their adoption, evaluation and continued evolution through worldwide multi-institutional cooperation. +
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