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'''<big>iGEM 2005</big> - The summer 2005 intercollegiate Genetically Engineered Machine competition.'''
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'''
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==Participating Schools==
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{| width=400 align=center
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|[[Berkeley]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Berkeley Parts]
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|[[Caltech]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Caltech Parts] [http://www.cds.caltech.edu/~murray/synbio/wiki/index.php WIKI] 
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|- 
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|[[Cambridge]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Cambridge Parts] [http://www.ccbi.cam.ac.uk/iGEM2005/index.php/Main_Page WIKI]
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|[[Davidson]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Davidson Parts]
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|-
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|[[ETH Zurich]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_ETHZ Parts]
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|[[Harvard]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Harvard Parts] [http://karma.med.harvard.edu/wiki/iGEM_2005 WIKI]
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|-
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|[http://model.mit.edu/igem/index.php?title=People MIT] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_MIT Parts] [http://model.mit.edu/igem WIKI]
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|[[Oklahoma]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Oklamhoma Parts]
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|-
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|[[Penn State]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Penn_State Parts]
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|[[Princeton]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Princeton Parts] [http://ehukai.ee.princeton.edu/wi/index.php WIKI]
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|-
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|[[Toronto]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Toronto Parts]
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|[[UCSF]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UCSF Parts]
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|-
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|[[UT Austin]] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UTAustin Parts]
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|[http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Registry Registry Parts]
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|}
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==Events==
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*[http://parts2.mit.edu/r/parts/htdocs/iGEM2005/ttt.cgi Teacher's Workshop] - May 15-15, 2005
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**[[Parts, Devices, Systems & Engineering Theory]]
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**[[Risks and Rewards]]
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**[[Notes on Tom Knight's talk]]
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**[http://web.mit.edu/endy/www/scraps/talks/iGEM/Silver.yeast.ppt Pam Silver's yeast powerpoint]
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*Jamboree, November 5-6, 2005 (to change the name of the Jamboree, please send Drew Endy a check for $30,000,000)
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==Papers for Students to Read==
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===General Review Papers===
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*A. Malcolm Campbell. 2005. Meeting Report: Synthetic Biology Jamboree for Undergraduates. Cell Biology Education. 4: 19 - 23. (Meeting Report for 2004 Jamboree) [http://www.cellbioed.org/pdf/04-11-0047.pdf URL]
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*Dan Ferber. 2004. Microbes Made to Order. Science. Vol. 303: 158 - 161. (Good general overview), [http://www.sciencemag.org/cgi/content/full/303/5655/158 URL]
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*Jeff Hasty, David McMillen, and J. J. Collins. 2002. Engineered Gene Circuits. Nature. Vol. 420: 224 - 230. (Scholarly Review Paper), [http://www.nature.com/nature/journal/v420/n6912/abs/nature01257_fs.html URL]
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*Philip Ball. 2004. Starting from Scratch. Nature. Vol. 431: 624 - 626. (OK general overview), [http://www.nature.com/news/2004/041004/pf/431624a_pf.html URL]
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*Editors of Nature. 2004. Futures of Artificial Life. Nature. Vol. 431: 613. (Editorial that addresses ethical considerations), [http://www.bio.davidson.edu/courses/synthetic/papers/Synthetic_Editorial.pdf URL]
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===Research Papers in Synthetic Biology===
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*Timothy S. Gardner, Charles R. Cantor, and James J. Collins.  2000.  Construction of a genetic toggle switch in Escherichia coli.  Nature. Vol. 403.  339 - 342. (Bistable gene regulatory network, toggled by transient chemical or thermal induction, to serve as cellular memory)
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*Robert T. Batey, Sunny D. Gilbert, and Rebecca K. Montange. 2004. Structure of a Natural Guanine-responsive Riboswitch Complexed with a Metabolite Hypoxanthine. Nature. Vol. 432. 411 - 415. (Distinguishes Riboswitches from Aptamers and Antiswitches; also shows 3D structure of aptamer and ligand)
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*News Summary of Batey et al. 2004. (Batey et al., paper above)
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*Laising Yen et al. 2004. Exogenous Controlof Mammalian Gene Expression through Modulation of RNA Self-cleavage. Nature. Vol. 431: 471 - 476. (mRNA-mediated regulation of translation)
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*Yina Kuang, Israel Biran, and David R. Walt. 2004. Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays. Analytical Chemistry. Vol. 76: 6282 - 6286. (Analysis of two promoters)
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*Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Conner, and James C. Liao.  2004. Design of artificial cell-cell communication using gene and metabolic networks.  PNAS. 101(8): 2299-2304.  (Quorum sensor using acetate signal)
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*Hideki Kobayashi, Mads Kaern, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins.  Programmable cells: Interfacing natural and engineered gene networks. PNAS. 101(22): 8414-8419. (Toggle switch interfaced with 1) SOS signaling pathway for DNA damage response and 2) quorum sensing signalling pathway)
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*Sara Hooshangi, Stephan Thiberge, and Ron Weiss. 2005. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. PNAS. 102(10): 3581–3586. (Basic Research Paper)
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*Bayer, Travis S. and Christina D . Smolke. 2005. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23 (3): 337 - 343. (Antiswithces that turn off or on mRNA translation, regulated by amptamer binding ligands)
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*Isaacs, Farren J. and James J. Collins. 2005. Plug-and-play with RNA. Nature Biotechnology. 23 (3): 306 -307. (Commentary on Bayer & Smolke, 2005.)
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* Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss. 2005. A synthetic multicellular system for programmed pattern formation. Nature. Vol. 434:1130-1134 (Cool patterns, seeded with senders, with receivers responding to chemical gradients) [http://www.nature.com/nature/journal/v434/n7037/abs/nature03461.html URL]
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===Mathematical Modeling in Synthetic Biology===
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* Hasty J, McMillen D, Isaacs F, Collins JJ. 2001. Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet. 2001 Apr;2(4):268-79.
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* Guet, C&abreve;lin C., Elowitz, Michael B., Hsing, Weihong, Leibler, Stanislas Combinatorial Synthesis of Genetic Networks Science 2002 296: 1466-1470
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* McAdams HH, Arkin A. Simulation of prokaryotic genetic circuits. Annu Rev Biophys Biomol Struct. 1998; 27:199-224. [http://dx.doi.org/10.1146/annurev.biophys.27.1.199 Link]
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==Possible Fun Groups==
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#[[Awards Panel]]
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#[[Jamboree Planning]]
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#[[Editorial Board]]
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#[[Standards of Practice]]
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#[[iGEM 2006 Planning]]
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#[[Others (Publicity?)]]
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==Resources==
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#[[Blue Heron Point of Contact]]
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#[[Part Nicknames]]
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#[[Lab Protocols]]
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Please see [http://meta.wikipedia.org/wiki/MediaWiki_i18n documentation on customizing the interface]
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and the [http://meta.wikipedia.org/wiki/MediaWiki_User%27s_Guide User's Guide] for usage and configuration help.
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==Funding==
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iGEM is an initiative of the MIT [http://icampus.mit.edu/ iCampus] program, which is funded by Microsoft Corp. iCampus sponsors faculty innovations in educational technology, helps incubate them through classroom use, and promotes their adoption, evaluation and continued evolution through worldwide multi-institutional cooperation.
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Revision as of 18:43, 7 October 2005

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