Research Papers in Synthetic Biology

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Timothy S. Gardner, Charles R. Cantor, and James J. Collins. Nature 2000. Construction of a genetic toggle switch in Escherichia coli. (Bistable gene regulatory network, toggled by transient chemical or thermal induction, to serve as cellular memory) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10659857&query_hl=2&itool=pubmed_docsum Pubmed] [http://www.nature.com/nature/journal/v403/n6767/abs/403339a0.html;jsessionid=CFE6987D6A70E6800842DA88D0C63536 Journal]

Robert T. Batey, Sunny D. Gilbert, and Rebecca K. Montange. Nature 2004. Structure of a Natural Guanine-responsive Riboswitch Complexed with a Metabolite Hypoxanthine. (Distinguishes Riboswitches from Aptamers and Antiswitches; also shows 3D structure of aptamer and ligand) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15549109&query_hl=4&itool=pubmed_docsum Pubmed] [http://www.nature.com/nature/journal/v432/n7015/abs/nature03037.html Journal]

Laising Yen et al. Nature 2004. Exogenous Controlof Mammalian Gene Expression through Modulation of RNA Self-cleavage. (mRNA-mediated regulation of translation) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15386015&query_hl=7&itool=pubmed_docsum Pubmed] [http://www.nature.com/nature/journal/v431/n7007/abs/nature02844.html Journal]

Yina Kuang, Israel Biran, and David R. Walt. 2004. Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays. Analytical Chemistry. (Analysis of two promoters) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15516119&query_hl=9&itool=pubmed_docsum Pubmed] [http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ac049053f Journal]

Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Conner, and James C. Liao. PNAS 2004. Design of artificial cell-cell communication using gene and metabolic networks. (Quorum sensor using acetate signal) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14983004&query_hl=11&itool=pubmed_docsum Pubmed]

Hideki Kobayashi, Mads Kaern, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins. Programmable cells: Interfacing natural and engineered gene networks. PNAS. 101(22): 8414-8419. (Toggle switch interfaced with 1) SOS signaling pathway for DNA damage response and 2) quorum sensing signalling pathway)

Sara Hooshangi, Stephan Thiberge, and Ron Weiss. 2005. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. PNAS. 102(10): 3581–3586. (Basic Research Paper)

Bayer, Travis S. and Christina D . Smolke. 2005. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23 (3): 337 - 343. (Antiswithces that turn off or on mRNA translation, regulated by amptamer binding ligands)

Isaacs, Farren J. and James J. Collins. 2005. Plug-and-play with RNA. Nature Biotechnology. 23 (3): 306 -307. (Commentary on Bayer & Smolke, 2005.)

Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss. 2005. A synthetic multicellular system for programmed pattern formation. Nature. Vol. 434:1130-1134 (Cool patterns, seeded with senders, with receivers responding to chemical gradients) [http://www.nature.com/nature/journal/v434/n7037/abs/nature03461.html URL]