Brown:Tri-Stable toggle switch

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(Modeling of the tristable switch)
(Modeling of the tristable switch)
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=Modeling of the tristable switch=
=Modeling of the tristable switch=
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While the tri-stable switch is seemingly simple in design, just like any other system it is subject potentially factors promoter leakiness and stochastic fluctuation. Thus in an attempt to predict the behavior of the tri-stable switch, we created a deterministic model of the system taking into account these confounding factors.  The model design While This model is a work in progress  
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While the tri-stable switch is seemingly simple in design, just like any other system it is subjected to potentially comprising factors such as promoter leakiness and other stochastic fluctuations. Thus in an attempt to predict the behavior of the tri-stable switch, we created a deterministic model of the system taking into account these factors.  The model design While This model is a work in progress  
==Derivation of the Model Equations==
==Derivation of the Model Equations==

Revision as of 00:24, 28 October 2006

Contents

Modeling of the tristable switch

While the tri-stable switch is seemingly simple in design, just like any other system it is subjected to potentially comprising factors such as promoter leakiness and other stochastic fluctuations. Thus in an attempt to predict the behavior of the tri-stable switch, we created a deterministic model of the system taking into account these factors. The model design While This model is a work in progress

Derivation of the Model Equations

Reaction Equations

Fast Reaction Equations

The following equations describe the fast reactions the L,T,A denote monomers of LacI, TetR, and, AraC, respectively.

Fast rxn eqs1.png










link to MATLAB code of model tristable1.m

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