Brown:Tri-Stable toggle switch

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Modeling of the tristable switch

While the tri-stable switch is seemingly simple in design, in reality of the is chaos plagued with promoter leakiness and stochastic fluctuation. In an attempt to predict the behavior of the tri-stable switch, we created a deterministic model of the system taking these factors into account. The model design While This model is a work in progress

Derivation of the Model Equations

Reaction Equations

Fast Reaction Equations

The following equations describe the fast reactions the L,T,A denote monomers of LacI, TetR, and, AraC, respectively.

Fast rxn eqs1.png










link to MATLAB code of model tristable1.m

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