Freiburg University 2006
From 2006.igem.org
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The team (all stars)
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The motto
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The project: DNA Folding
ProjectsNo.1 - The Pipe The idea is to design a strand of DNA such that it wraps into a specific shape. There are three different stages for this project: First, the DNA should fold into a two-dimensional rectangular sheet. Secondly, this sheet should wrap itself up into the shape of a short pipe. And last, these little pipes should hook themselves up to each other such that they form one single long pipe (more details).
No.2 - Haute Couture: Barbie Nanoatelier Once the process of DNA folding into 3D structures is understood, shapes can be chosen arbitrarily. The idea of the Barbie Nanoatelier is that the DNA should wrap into a 3D T-Shirt, 3D Pants, etc. "sea of parts" We need a library of molecular primitives that could be interchanged in the desirable way for a bottom-up design on the nanometer scale. Registry of DNA molecular parts and standardization is an actual question of bionanotechnology. We just put first examples of a new class of BioBricks - ORIGAMI BioBriks into [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2006partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2006&group=Freiburg depository] and publish basic ideas [http://omnibus.uni-freiburg.de/~kouznet/DNA-plug.txt], [http://omnibus.uni-freiburg.de/~kouznet/T-shirt.txt], [http://omnibus.uni-freiburg.de/~kouznet/DNA-NanoSwarm.txt]. We try to merge a ‘dead DNA’ with an ‘alive DNA’ [*]. Surrealistic Science We also try to pump some aesthetic principles and rules (symmetry, periodic patterns, recursion, and plasticity) into our creatures. We like it because it needs a huge of imagination and really very difficult. Nobody can build a bra! - von Neumann's self-reproducing ... bra :))
Sketches - T-Shirt from DNA
 The DNA sequence for the T-Shirt design can be found [http://omnibus.uni-freiburg.de/~kouznet/t-shirt/T-shirt_M13mp18_NEB_d.txt here], the picture is [http://omnibus.uni-freiburg.de/~kouznet/t-shirt/T-shirt.jpg here], and the staples are [http://omnibus.uni-freiburg.de/~kouznet/t-shirt/T-shirt_staples.txt here] there. Hey, venture capitalists, where are you? The price of all of 50 billion T-Shirts would be only 7200bases x €0.17/base = €1224. Don’t miss the chance. It could be a great business tomorrow! Ladies and Gentlemen, please, visit the demonstration of last Nike nano collection. (Enter) Oh, aroma of the podium [http://omnibus.uni-freiburg.de/~kouznet/LoveParade2005.mp3 music] Jobs: Still looking for catwalk models!!
No.3 - Individual projectsOther projects and prices could be found on individual Mutant's pages (Real iPod nano, Captain Nemo). In addition, you can find some hot information on ‘GEM Freiburg Fellow 2006’ page. The other toys will be unconventional computing, cryptography, nanoelectronics, nanooptics, drug delivery systems, smart nanomaterials, nanoswarm, eventually an artificial life and Origami Man. Time is money! |
GEM Freiburg
Club
SB Preliminary
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Original ideas
Now we see it could be cheaper, but it will need a great intellectual impact. So, we’re opened for sponsors and relationships. CommentsAs I understand it, the idea is to create a "life automaton" consisting of 6 proteins? That is what I took out of your proposal. That seems quite ambitioned, but I can't really judge it, and even if it is quite ambitioned, that does not mean that it is bad, of course. My understanding says that you are using 6000 € for denovo synthesis of 6 genes required for making minimal life. Right? So, what if after all the simulations and tests on the computer, you order the DNA for minimal life and it turns out that it doesn't work... What will you do then? This is because biology is unpredictable and you must not assume that the DNA which you order will work in the first time itself... You must keep some backup money or plans... You have to separate specifically the general and specific objectives to long and short time; implications, obstacles and limitations. OK, fine.. So you want to go in a completely different direction by creating alternative life.. Good.. All the best for this project. Well, if you want to go to the extremes then are you limiting yourself to already established phenomena such as DNA, membranes, etc. You may want to adopt a completely new and novel ideas which might be simpler than DNA and other stuff of the normal cell. So, keep all the options open. Research the literature well and create Artificial Life... |
Hey Mutant, have a look!
The easy and serious way
These people do great thingsAlbert Libchaber [http://www.rockefeller.edu/research/abstract.php?id=93]
Carlos Bustamante's lab [http://alice.berkeley.edu/]
David Deamer [http://www.chemistry.ucsc.edu/deamer_d.html]
Eric Kool’s group [http://www.stanford.edu/group/kool/]
Erik Winfree [http://www.dna.caltech.edu/~winfree/]
Fred Menger’s group [http://www.chemistry.emory.edu/faculty/menger/index.html]
Jack Szostak’s lab [http://genetics.mgh.harvard.edu/szostakweb/]
Ned Seeman's lab [http://seemanlab4.chem.nyu.edu/]
Peixuan Guo [http://www.vet.purdue.edu/PeixuanGuo/index.html]
Pier Luigi Luisi’s group [http://www.plluisi.org/index.html]
'Protolife' by Norman Packard & Mark Bedau [http://www.protolife.net/]
Radhika Nagpal [http://www.eecs.harvard.edu/~rad/]
Steen Rasmussen [http://www.ees.lanl.gov/staff/steen/]
Steven Benner [http://www.chem.ufl.edu/benner.html] LocalAn Analysis of Synthetic Biology Research in Europe and North America [http://www2.spi.pt/synbiology/] SB database [http://www.synthetic-biology.info/] DNA synthesis: ATG-Biosynthetics [http://www.atg-biosynthetics.com/] febit [http://febit.de/europe/en/] 'Spiegel' about iGEM competition on August 14, 2006 [http://www.spiegel.de/spiegel/0,1518,431399,00.html] 'Neue Zürcher Zeitung' about SB on August 23, 2006 [http://www.nzz.ch/2006/08/23/ft/articleEEA5E.html] New GEM on the simiki wiki page [http://ernie.imtek.uni-freiburg.de/simiki/GeneticallyEngineeredMachines] |
