University of Michigan 2006


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We're the iGEM team from the University of Michigan.



  • 2006.03.15 We opened our wiki page!


Mailing Address

Peter Woolf
Department of Chemical Engineering
2300 Hayward St.
3074 H.H. Dow Building
Ann Arbor, MI 48109-2136



Not pictured here:


Our Project

From Design to Manufacturing

1. Plasmene 
Plasmene is the first integrated development environment designed specifically for synthetic biology. Plasmene is designed to be a central component in the development process of synthetic genetic networks. Plasmene hopes to integrate the three major components of synthetic genetic network development, typology design, modeling results, and fabrication information, into a common environment. Plasmene will also provide connections to major databases in order to make it easier for users to pull information from the Internet into their projects. The Plasmene project's goal is to increase the productivity of synthetic biologists by freeing the user from the hassle of simple, time-consuming tasks and allowing the researcher to spend more time performing useful research.

Download Proof of Principle Prototype: Plasmine

2. Recursive Landing Pads 
A super-duper-awesomely innovative method for inserting genes and DNA sequences onto E. coli's chromosome (that Steve can explain much better than I can, and hopefully he will as soon as he gets back from class).
3. Modeling Oscillatory Behavior of Clocks 
A look at the parameter space of clocks and genetic oscillating devices, primarily examining the ideal conditions for generating oscillations.
4. Experimental Manipulation of Lac Operon Kinetic Order 
XsomesOp.gif Experimental assays of strains and plasmids with Op sinks were performed. Strains were created by inserting sinks on chromosome. Landing pads included rbs, glnK and trp regions. Results showed the following: - Sinks on plasmid raise basal level of lacZ expression; - Sinks on chromosome raise kinetic order; - One strain in particular was of significant interest. Findings can be used for "tuning" genetic systems (clocks, oscillators, etc).



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