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iGEM 2005 The summer 2005 intercollegiate Genetically Engineered Machine competition.

Contents

Participating Schools

Click to see each team's parts

  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Berkeley Berkeley]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Caltech Caltech]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Cambridge Cambridge]

Davidson College Synth-Aces

[http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Davidson Davdison Parts in Registry]

[http://www.bio.davidson.edu/courses/synthetic/students.html Summer 2005 Research Students]

  • Links to Courses
    • [http://www.bio.davidson.edu/courses/synthetic/synthetic.html Synthetic Lab Course Fall 2005]
    • [http://www.bio.davidson.edu/genomics Genomics Lecture Course (with Systems Biology and Synthetic Biology Sections)]
    • [http://www.bio.davidson.edu/programs/Genomics/concentration.html Genomics Concentration (interdiciplinary minor)]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_ETHZ ETH_Zurich]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Harvard Harvard] 
If you would like help setting up a [http://karma.med.harvard.edu/wiki/iGEM_2005 WIKI], please, contact [http://karma.med.harvard.edu/wiki/User_talk:Alexanderwait me]!
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_MIT MIT]
    • [http://model.mit.edu/igem/ MIT team's WIKI]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Oklamhoma Oklahoma]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Penn_State Penn State]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Princeton Princeton]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Toronto Toronto]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UCSF UCSF]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UTAustin UT Austin]
  • [http://rosalind.csail.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Registry Registry]

Events

Papers for Students to Read

General Review Papers

  • A. Malcolm Campbell. 2005. Meeting Report: Synthetic Biology Jamboree for Undergraduates. Cell Biology Education. 4: 19 - 23. (Meeting Report for 2004 Jamboree) [http://www.cellbioed.org/pdf/04-11-0047.pdf URL]
  • Dan Ferber. 2004. Microbes Made to Order. Science. Vol. 303: 158 - 161. (Good general overview), [http://www.sciencemag.org/cgi/content/full/303/5655/158 URL]
  • Jeff Hasty, David McMillen, and J. J. Collins. 2002. Engineered Gene Circuits. Nature. Vol. 420: 224 - 230. (Scholarly Review Paper), [http://www.nature.com/nature/journal/v420/n6912/abs/nature01257_fs.html URL]
  • Philip Ball. 2004. Starting from Scratch. Nature. Vol. 431: 624 - 626. (OK general overview), [http://www.nature.com/news/2004/041004/pf/431624a_pf.html URL]
  • Editors of Nature. 2004. Futures of Artificial Life. Nature. Vol. 431: 613. (Editorial that addresses ethical considerations), [http://www.bio.davidson.edu/courses/synthetic/papers/Synthetic_Editorial.pdf URL]

Research Papers in Synthetic Biology

  • Timothy S. Gardner, Charles R. Cantor, and James J. Collins. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature. Vol. 403. 339 - 342. (Bistable gene regulatory network, toggled by transient chemical or thermal induction, to serve as cellular memory)
  • Robert T. Batey, Sunny D. Gilbert, and Rebecca K. Montange. 2004. Structure of a Natural Guanine-responsive Riboswitch Complexed with a Metabolite Hypoxanthine. Nature. Vol. 432. 411 - 415. (Distinguishes Riboswitches from Aptamers and Antiswitches; also shows 3D structure of aptamer and ligand)
  • News Summary of Batey et al. 2004. (Batey et al., paper above)
  • Laising Yen et al. 2004. Exogenous Controlof Mammalian Gene Expression through Modulation of RNA Self-cleavage. Nature. Vol. 431: 471 - 476. (mRNA-mediated regulation of translation)
  • Yina Kuang, Israel Biran, and David R. Walt. 2004. Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays. Analytical Chemistry. Vol. 76: 6282 - 6286. (Analysis of two promoters)
  • Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Conner, and James C. Liao. 2004. Design of artificial cell-cell communication using gene and metabolic networks. PNAS. 101(8): 2299-2304. (Quorum sensor using acetate signal)
  • Hideki Kobayashi, Mads Kaern, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins. Programmable cells: Interfacing natural and engineered gene networks. PNAS. 101(22): 8414-8419. (Toggle switch interfaced with 1) SOS signaling pathway for DNA damage response and 2) quorum sensing signalling pathway)
  • Sara Hooshangi, Stephan Thiberge, and Ron Weiss. 2005. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. PNAS. 102(10): 3581–3586. (Basic Research Paper)
  • Bayer, Travis S. and Christina D. Smolke. 2005. Programable ligand-conrolled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23 (3): 337 - 343. (Antiswithces that turn off or on mRNA translation, regulated by amptamer binding ligands)
  • Isaacs, Farren J. and James J. Collins. 2005. Plug-and-play with RNA. Nature Biotechnology. 23 (3): 306 -307. (Commentary on Bayer & Smolke, 2005.)
  • Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss. 2005. A synthetic multicellular system for programmed pattern formation. Nature. Vol. 434:1130-1134 (Cool patterns, seeded with senders, with receivers responding to chemical gradients)

Possible Fun Groups

  1. Awards Panel
  2. Jamboree Planning
  3. Editorial Board
  4. Standards of Practice
  5. iGEM 2006 Planning
  6. Others (Publicity?)

Resources

  1. Blue Heron Point of Contact
  2. Part Nicknames
  3. Lab Protocols

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