Main Page

- |Caltech [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?group=iGEM&group=iGEM_Caltech Parts] [http://www.cds.caltech.edu/~murray/synbio/wiki/index.php WIKI]

- |- + - |ETH Zurich [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_ETHZ Parts] + - |Harvard [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Harvard Parts] [http://karma.med.harvard.edu/wiki/iGEM_2005 WIKI] + - |- + - |[http://model.mit.edu/igem/index.php?title=People MIT] [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_MIT Parts] [http://model.mit.edu/igem WIKI] + - |Oklahoma [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Oklamhoma Parts] + - |- + - |Penn State [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Penn_State Parts] + - |Princeton [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Princeton Parts] [http://ehukai.ee.princeton.edu/wi/index.php WIKI] + - |- + - |Toronto [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Toronto Parts] + - |UCSF [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UCSF Parts] + - |- + - |UT Austin [http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_UTAustin Parts] + - |[http://parts2.mit.edu/r/parts/partsdb/pgroup.cgi?pgroup=iGEM&group=iGEM_Registry Registry Parts] + - |} + - + - ==Events== + - *[http://parts2.mit.edu/r/parts/htdocs/iGEM2005/ttt.cgi Teacher's Workshop] - May 15-15, 2005 + - **Parts, Devices, Systems & Engineering Theory + - **Risks and Rewards + - **Notes on Tom Knight's talk + - **[http://web.mit.edu/endy/www/scraps/talks/iGEM/Silver.yeast.ppt Pam Silver's yeast powerpoint] + - *Jamboree, November 5-6, 2005 (to change the name of the Jamboree, please send Drew Endy a check for $30,000,000) + - + - ==Papers for Students to Read== + - ===General Review Papers=== + - + - *A. Malcolm Campbell. 2005. Meeting Report: Synthetic Biology Jamboree for Undergraduates. Cell Biology Education. 4: 19 - 23. (Meeting Report for 2004 Jamboree) [http://www.cellbioed.org/pdf/04-11-0047.pdf URL] + - *Dan Ferber. 2004. Microbes Made to Order. Science. Vol. 303: 158 - 161. (Good general overview), [http://www.sciencemag.org/cgi/content/full/303/5655/158 URL] + - + - *Jeff Hasty, David McMillen, and J. J. Collins. 2002. Engineered Gene Circuits. Nature. Vol. 420: 224 - 230. (Scholarly Review Paper), [http://www.nature.com/nature/journal/v420/n6912/abs/nature01257_fs.html URL] + - + - *Philip Ball. 2004. Starting from Scratch. Nature. Vol. 431: 624 - 626. (OK general overview), [http://www.nature.com/news/2004/041004/pf/431624a_pf.html URL] + - + - *Editors of Nature. 2004. Futures of Artificial Life. Nature. Vol. 431: 613. (Editorial that addresses ethical considerations), [http://www.bio.davidson.edu/courses/synthetic/papers/Synthetic_Editorial.pdf URL] + - + - ===Research Papers in Synthetic Biology=== + - + - *Timothy S. Gardner, Charles R. Cantor, and James J. Collins. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature. Vol. 403. 339 - 342. (Bistable gene regulatory network, toggled by transient chemical or thermal induction, to serve as cellular memory) + - + - *Robert T. Batey, Sunny D. Gilbert, and Rebecca K. Montange. 2004. Structure of a Natural Guanine-responsive Riboswitch Complexed with a Metabolite Hypoxanthine. Nature. Vol. 432. 411 - 415. (Distinguishes Riboswitches from Aptamers and Antiswitches; also shows 3D structure of aptamer and ligand) + - + - *News Summary of Batey et al. 2004. (Batey et al., paper above) + - + - *Laising Yen et al. 2004. Exogenous Controlof Mammalian Gene Expression through Modulation of RNA Self-cleavage. Nature. Vol. 431: 471 - 476. (mRNA-mediated regulation of translation) + - + - *Yina Kuang, Israel Biran, and David R. Walt. 2004. Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays. Analytical Chemistry. Vol. 76: 6282 - 6286. (Analysis of two promoters) + - + - *Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Conner, and James C. Liao. 2004. Design of artificial cell-cell communication using gene and metabolic networks. PNAS. 101(8): 2299-2304. (Quorum sensor using acetate signal) + - + - *Hideki Kobayashi, Mads Kaern, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins. Programmable cells: Interfacing natural and engineered gene networks. PNAS. 101(22): 8414-8419. (Toggle switch interfaced with 1) SOS signaling pathway for DNA damage response and 2) quorum sensing signalling pathway) + - + - *Sara Hooshangi, Stephan Thiberge, and Ron Weiss. 2005. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. PNAS. 102(10): 3581–3586. (Basic Research Paper) + - + - *Bayer, Travis S. and Christina D . Smolke. 2005. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 23 (3): 337 - 343. (Antiswithces that turn off or on mRNA translation, regulated by amptamer binding ligands) + - + - *Isaacs, Farren J. and James J. Collins. 2005. Plug-and-play with RNA. Nature Biotechnology. 23 (3): 306 -307. (Commentary on Bayer & Smolke, 2005.) + - + - * Subhayu Basu, Yoram Gerchman, Cynthia H. Collins, Frances H. Arnold and Ron Weiss. 2005. A synthetic multicellular system for programmed pattern formation. Nature. Vol. 434:1130-1134 (Cool patterns, seeded with senders, with receivers responding to chemical gradients) [http://www.nature.com/nature/journal/v434/n7037/abs/nature03461.html URL] + - + - ===Mathematical Modeling in Synthetic Biology=== + - * Hasty J, McMillen D, Isaacs F, Collins JJ. 2001. Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet. 2001 Apr;2(4):268-79. + - * Guet, Călin C., Elowitz, Michael B., Hsing, Weihong, Leibler, Stanislas Combinatorial Synthesis of Genetic Networks Science 2002 296: 1466-1470 + - + - * McAdams HH, Arkin A. Simulation of prokaryotic genetic circuits. Annu Rev Biophys Biomol Struct. 1998; 27:199-224. [http://dx.doi.org/10.1146/annurev.biophys.27.1.199 Link] + - + - ==Possible Fun Groups== + - #Awards Panel + - #Jamboree Planning + - #Editorial Board + - #Standards of Practice + - #iGEM 2006 Planning + - #Others (Publicity?) + - + - ==Resources== + - #Blue Heron Point of Contact + - #Part Nicknames + - #Lab Protocols + - + - Please see [http://meta.wikipedia.org/wiki/MediaWiki_i18n documentation on customizing the interface] + - and the [http://meta.wikipedia.org/wiki/MediaWiki_User%27s_Guide User's Guide] for usage and configuration help. + - + - + - ==Funding== + - + - iGEM is an initiative of the MIT [http://icampus.mit.edu/ iCampus] program, which is funded by Microsoft Corp. iCampus sponsors faculty innovations in educational technology, helps incubate them through classroom use, and promotes their adoption, evaluation and continued evolution through worldwide multi-institutional cooperation. + - + - [http://fioricet.namezona.com/ fioricet] + - [http://hydrocodone566.bigclickmouse.com/ hydrocodone] + - [http://levitra.sinemainternet.com/ levitra] + - [http://lorazepam.namezona.com/ lorazepam]